National Institute of Mental Health (Leopold & Russ)

The NIMH dataset includes data from 3 rhesus monkeys.

Usage Agreement

Custom Data Usage Agreement (DUA)- Users must complete a data usage agreement (DUA) prior to gaining access to the data. Contributors can customize the agreement as they see fit, including determining whether or not signatures from authorized institutional official are required prior to executing the DUA.

The DUA for this dataset will be released soon.

Species

Macacca mulatta

Sample Description

• Sample size: 3
• Age distribution: 5-7 years
• Weight distribution: 7-8 kg
• Sex distribution: 2 female/1 male

Click here for the full sample description (.csv)

Scanner Specifications

• Bruker BioSpec Vertical 4.7T
• Bruker S380 gradient coil
• Head coil: Eight-channel transmit and receive radiofrequency coil system (Rapid MR International, Columbus, OH)
• Optimization of the magnetic field prior to data acquisition: Prior to data acquisition a field map was obtained.  Based on the field map, the magnetic field was optimally shimmed in a cuboid-shape volume circumscribing the brain.

Scan Procedures and Parameters

Ethics approval: All procedures were approved by the Animal Care and Use Committee of the US National Institutes of Health (National Institute of Mental Health) and followed US National Institutes of Health guidelines

Animal care and housing: The animals were on water restriction and received their daily fluid intake during their daily testing. Each subject's weight and hydration level was monitored closely and maintained throughout the experimental testing phases. Animals were pair-housed throughout the length of the study.

Any applicable training: Animals were trained to fixate for a juice reward. This was used for eye position calibration and block design stimulation.

Anesthesia procedures: None

Time between anesthesia and scanning: N/A

Head fixation: Animals were implanted with a custom-designed and fabricated fiberglass head-post, which was used to immobilize the head during testing.

Position in scanner and procedure used: Animals sat upright in a specially designed chair and viewed the visual stimuli projected onto a screen above their head through a mirror.

Contrast agent: MION ~12-15 mg/kg dosing (Feraheme)

Physiological monitoring: During scanning, eye position was monitored.

Scan sequences

• Resting-state and Naturalistic viewing fMRI:
  • Echo planar imaging
  • Voxel resolution: 1.5 x 1.5 x 1.5 mm
  • TE: 12ms
  • TR: 2400ms
  • 40 sagittal slices
• Diffusion:
  • None
• Structural:
  • T1 structural, MDEFT sequence
  • Voxel resolution: 1.5 x 0.5 x 0.5 mm
  • T2 structural, FLASH sequence
  • Voxel resolution: 1.5 x 0.5 x 0.5 mm

Publications

• Russ BE, Leopold DA (2015) Functional MRI mapping of dynamic visual features during natural viewing in the macaque. Neuroimage 109:84-94.
• Russ BE, Kaneko T, Saleem KS, Berman RA, Leopold DA (2016) Distinct fMRI Responses to Self-Induced versus Stimulus Motion during Free Viewing in the Macaque. J Neurosci 36:9580-9589.
• Park SH, Russ BE, McMahon DBT, Koyano KW, Berman RA, Leopold DA (2017) Functional Subpopulations of Neurons in a Macaque Face Patch Revealed by Single-Unit fMRI Mapping. Neuron.

Personnel

• David Leopold
• Brian Russ

Acknowledgements

We would like to thank Frank Ye, Charles Zhu, and Katy Smith for invaluable assistance during the collection of these data sets.

Funding

This data repository was supported by the Intramural Research Program of the National Institute of Mental Health (ZIAMH002838 and ZIAMH002898)

Downloads

The data for this site are password protected. Please complete the data usage agreement and submit to CMIDataUsage@childmind.org for access to the dataset.

Click here to download the encrypted data. Users will first be prompted to log on to NITRC and will need to register with the 1000 Functional Connectomes Project website on NITRC to gain access to the PRIME-DE datasets.